New International Collaboration On Cosmetics Safety Aims To Advance Acceptance Of Animal-Free Science Worldwide

February 8, 2023

Global collaboration of cosmetics and chemicals industry experts will work together with animal protection NGOs to accelerate widespread use of animal-free safety science through research, education and regulatory engagement.

NewYork, NY — Today, more than 35 cosmetics manufacturers and suppliers, industry associations and animal protection organizations announced the launch of the International Collaboration on Cosmetics Safety (ICCS) to ensure animal-free methods are accepted and used by everyone involved in cosmetics safety testing. ICCS will support animal-free cosmetics and personal care product and ingredient innovation by funding rigorous, scientific evaluation of new animal-free safety assessment approaches. It will share the results of these evaluation activities with cosmetic and chemical regulators and fund education and training activities to help build confidence in animal-free safety assessment approaches.


“We have seen significant scientific advancements in the development, evaluation and use of animal-free methods for safety assessment in recent decades,” said Erin Hill, president and CEO of ICCS. “ICCS brings together scientists from leading organizations around the world to continue this momentum and work toward our shared ambition for a future where no ingredients or products are tested on animals. ICCS is a global collaboration focused on animal-free safety science for cosmetics and ingredients, which currently face unique challenges and inconsistent global regulations. I am honored to lead the organization at such an important time.”


Hill comes to ICCS from the Institute for In Vitro Sciences (IIVS), which she co-founded in 1997 and most recently served as president. IIVS is a non-profit research and testing laboratory dedicated to the use and acceptance of non-animal test methods worldwide. Hill brings extensive knowledge to the role of president and CEO of ICCS, having worked collaboratively with stakeholders to provide education and training in non-animal test methods. Her position at ICCS will allow her to draw on resources from IIVS and other members to create programs specifically designed to advance the acceptance of these new approaches for cosmetics and their ingredients.


ICCS will collaborate with existing organizations to:

 

  • Evaluate and further develop animal-free safety assessment approaches and demonstrate their scientific validity for human health and environmental protection.
  • Share the results of these evaluation activities with regulators to inform ongoing regulatory acceptance discussions around the world.
  • Provide education and training materials to accelerate widespread adoption of the latest animal-free safety science.
  • Through these efforts, ICCS is working to enable animal-free methods for cosmetics product and ingredient innovation globally.

 


“The safety of the cosmetics and personal care products that consumers use and trust every day is our top priority,” said John Chave, acting board chair of ICCS and director general of Cosmetics Europe. “Thanks to evolved scientific methods, we can ensure cosmetics and personal care product safety assessments are performed both rigorously and ethically, without animal testing. There is more to be done as science progresses, and multiple research projects are already underway at ICCS to further advance animal-free science methods.”


The cosmetics and personal care industry and animal protection organizations have been at the forefront of developing, evaluating and using animal-free safety assessment approaches for nearly 40 years. This includes significant contributions to the replacement of regulatory animal testing to address skin irritation, genetic toxicology, eye irritation and skin sensitization through innovative in silico and in vitro methodologies.


Today, while research and animal-free science methods have progressed, many policies and regulations still require animal test data and have not yet incorporated the rapid progress in applying innovative, animal-free science to safety assessment. This drives a need for animal data even where viable alternatives exist. ICCS aims to close this gap by understanding regulatory needs and supplying sound scientific solutions based on innovative animal-free approaches.

Press Release
October 16, 2025
The International Collaboration on Cosmetics Safety (ICCS) today announced that the Consumer Healthcare Products Association (CHPA) has joined its global network of non-governmental, trade/research organizations, and industry partners dedicated to advancing animal-free safety assessments for cosmetics and personal care products. “We are thrilled to welcome CHPA to ICCS,” said Erin Hill, President and CEO of ICCS. “Their leadership in consumer health and dedication to regulatory science will further strengthen our collective mission to promote innovative, human- and environmentally relevant safety assessment strategies. Especially at a time in the U.S., when the Food and Drug Administration is emphasizing reliable alternatives to animal testing, ICCS and its members are united in driving collaborative, science-led approaches that advance public health protection.” Jay Sirois, PhD, Vice President of Scientific and Regulatory Affairs at CHPA, said: “Joining ICCS reflects our shared commitment to modernizing safety evaluation across product categories. This collaboration will help ensure that scientific innovation and regulatory progress move hand in hand, supporting the ongoing development of safe, effective, and trusted self-care products.” The ICCS–CHPA collaboration comes at a pivotal moment following the FDA’s September 30, 2025, communication in which the Agency explicitly encouraged the development of new, reliable alternatives to animal testing for sunscreens. In response, ICCS is offering its support to help the FDA realize its plans for implementing New Approach Methodologies (NAMs) in sunscreen safety assessments. ICCS aims to help ensure that the FDA’s commitment to modern, animal-free science, already demonstrated in other regulatory areas, is fully realized in the sunscreen space. ICCS’ aligned efforts focus on advancing modern, science-based approaches to safety assessment that incorporate new technologies and internationally recognized best practices. The organization also supports a consistent and transparent regulatory framework that enables the broader application of NAMs across product categories. Through continued collaboration and knowledge sharing among regulators, industry, and NGOs, ICCS works to strengthen public health protection while fostering scientific innovation and regulatory modernization. By strengthening partnerships and advancing modern scientific tools, ICCS and its members are setting the stage for lasting progress in regulatory science and public health protection. About ICCS The International Collaboration on Cosmetics Safety is a global initiative headquartered in New York. It brings together scientists from industry, academia, and non-governmental organizations to promote the adoption and regulatory acceptance of animal-free safety science through education, research, and collaboration. Visit www.iccs-cosmetics.org About CHPA The Consumer Healthcare Products Association (CHPA), founded in 1881, is the national trade association representing the leading manufacturers and marketers of consumer healthcare products, including over-the-counter (OTC) medicines, dietary supplements, and OTC medical devices. CHPA is committed to empowering self-care by ensuring that Americans have access to products they can count on to be reliable, affordable, and convenient, while also delivering new and better ways to get and stay healthy. Visit www.chpa.org
July 21, 2025
The International Collaboration on Cosmetics Safety (ICCS) announces its first-ever Best Practice Guidance (BPG): “Skin Sensitization Assessment: Using New Approach Methods for Substances in Cosmetics and Personal Care Products.” This document marks the inaugural publication in a new series of ICCS Best Practice Guidance documents, developed to support the global transition to animal-free safety science. ICCS was invited to present the BPG at the Integrated Strategies for Safety Assessment of Cosmetics Joint Regulators-Industry Workshop hosted by the International Cooperation on Cosmetics Regulation (ICCR) on July 11, where regulators from more than 12 countries convened to advance non-animal methodologies. “This guidance reflects the collective expertise of ICCS members who came together to align on the development of this unique guidance,” said Erin Hill, President & CEO of ICCS. “It’s a key example of our mission to build global capacity and accelerate the uptake of animal-free safety assessments. We greatly appreciate the opportunity to collaborate with the ICCR to hear their input on the workflow in the document.” Grounded in Next Generation Risk Assessment (NGRA) principles, the BPG offers a structured, science-based workflow that includes practical steps from problem formulation, exposure assessment, data evaluation, to transparent decision-making. It is especially suited for safety assessors experienced in traditional methods but new to using NAMs. What Makes the ICCS BPG Unique This BPG builds on existing international frameworks—such as OECD test guidelines and ICCR principles—by integrating them into a cohesive, assessor-friendly workflow. It emphasizes practical use and real-world safety scenarios and is specifically designed for regulatory safety assessments of cosmetics and personal care products. Notably, the guidance provides tools for transparent decision-making, uncertainty characterization, and exposure-based waiving, offering assessors clear and pragmatic support for transitioning to animal-free science. Key Highlights of the BPG: Step-by-step workflow to guide assessors through skin sensitization hazard and safety assessments without new animal tests. Integration of in silico, in chemico, and in vitro methods, including those aligned with OECD Test Guidelines. Designed for regulatory use, especially for assessors transitioning from animal to non-animal approaches. The full guidance is now freely available for download on the ICCS Website . Looking Ahead The Skin Sensitization BPG is the first in a planned suite of ICCS Best Practice Guidance documents. Forthcoming documents planned are: eye and skin irritation, read-across, thresholds of toxicological concern (TTC), physiologically based kinetic (PBK) modeling, exposure-based waiving, and environmental safety endpoints. These guidance documents will continue to support ICCS’ goal of equipping the international community with practical tools for modern, human-relevant, and animal-free safety assessments.
Announcement
June 26, 2025
Explore the ICCS 2024 Annual Report! Dive into a year of progress in fostering regulatory collaboration, promoting harmonization, and strengthening global capacity. See how ICCS and its members contributed to advancing NAMs and NGRA—and helped shape a more modern, animal-free future.
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