Internal Exposure: Pilot Study to Evaluate a Methodology to Characterize the Kinetics of Serum Protein Binding to Inform Decision Making for Hepatic Clearance IVIVE for PBK Modelling
Objective
The objective of this project is to investigate the feasibility of measuring association / dissociation constants as source of data to inform on the likely effect on metabolism clearance extrapolation from differences in protein binding In Vitro
and In Vivo.
Project Details
Internal Exposure Working Group
Project Lead:
- Beate Nicol, Unilever
- Nazanin Golbamaki, L'Oréal