Toxicogenomics:  Method Standardization of Computational Approaches to Transcriptomics Data Processing and Concentration-Response Analyses

This proposal aims to address the following questions: 

1. How do we evaluate an expected level of performance of a technology to meet a defined set of specific required QC thresholds for dose-response data and thus benchmark both transcriptomics technologies that ICCS members currently use and future technologies? 
2. How do we calculate relevant points of departure and understand their technical limitations, define the signal to noise ratio and which methods do we include in phase II of our TGx tool development? 
3. The outputs will include data guidelines and evidence to support HTTr PoD determinations for future ICCS case studies and build confidence in the method for regulatory acceptance.