International Collaboration on Cosmetics Safety and the Cosmetic Ingredient Review Commit to a Working Partnership to Progress Sharing of Information and Collaboration

October 10, 2024

A logo for the international collaboration on cosmetic safety

WASHINGTON—The International Collaboration on Cosmetics Safety (ICCS) and the Cosmetic Ingredient Review (CIR) have committed to a partnership to further their efforts in exploring and increasing the exchange of information on cosmetic ingredient safety as it relates to New Approach Methodologies (NAMs) and Next Generation Risk Assessments (NGRAs).


ICCS, a global initiative focused on advancing the adoption of animal-free assessments of cosmetics, and CIR, a research organization that utilizes an expert panel for cosmetic ingredient safety, share similar scientific interests when it comes to the safety of the ingredients utilized in cosmetics.


“We welcome the opportunity for continued engagement with CIR as ICCS works to develop more human-predictive new approaches to further eliminate the need for testing in animals related to cosmetics,” said Erin Hill, CEO of ICCS.


The partnership will also include participation in regional and international meetings and scientific workshops related to cosmetics safety as well as the exchange of scientific research to expand the utilization of NAMs and NGRAs.


Through working together, ICCS will develop standardized best practice guidance on the use and understanding of NAMs and NGRAs to further their regulatory acceptance.


“By collaborating, we hope to foster a synergistic research sharing relationship that underscores the safety of ingredients used in cosmetics,” said Bart Heldreth, Executive Director, CIR.


A memorandum of understanding was signed by Hill and Heldreth today.


About ICCS

The International Collaboration on Cosmetics Safety (ICCS) is a global initiative focused on advancing the adoption of animal-free safety assessment approaches for cosmetics, personal care products and their ingredients. ICCS brings together scientists and experts from cosmetics manufacturers and suppliers, industry associations, and animal protection organizations to drive greater global awareness to accelerate widespread use of animal-free science through research, education & training, and regulatory engagement.


About CIR

The Cosmetic Ingredient Review was established in 1976 by the industry trade association (then the Cosmetic, Toiletry, and Fragrance Association, now the Personal Care Products Council), with the support of the U.S. Food and Drug Administration and the Consumer Federation of America. Although funded by the Council, CIR, the Expert Panel for Cosmetic Ingredient Safety, and the review process are independent from the Council and the cosmetics industry. CIR and the Expert Panel for Cosmetic Ingredient Safety operate under a set of procedures. For more information about CIR, visit www.cir-safety.org; for more information about the Expert Panel, visit ingredientsafetyexpertpanel.org

Announcement
April 6, 2026
We’re excited to share that the ICCS 2025 Annual Report is now available, highlighting a year of strong momentum driven by the expertise, engagement, and collaboration of our global membership. In 2025, ICCS members across industry, alongside partner organizations and trade and research associations, continued advancing animal-free safety science through practical tools, scientific outputs, and meaningful engagement with the regulatory community. What stands out most is the scale of this collective effort, turning innovation into real-world frameworks and global dialogue that support regulatory progress. Read the full report
Press Release
January 22, 2026
The International Collaboration on Cosmetics Safety (ICCS) today announced the election of its 2026 Board officers, confirmed at the organization’s December 2025 Board meeting. The newly elected leadership reflects ICCS’ continued commitment to advancing approaches in animal-free cosmetics safety.
January 8, 2026
In July 2025, the International Collaboration on Cosmetics Safety (ICCS) published its Best Practice Guidance (BPG) Document on Skin Sensitization Assessment , supporting the consistent and scientifically robust use of New Approach Methodologies (NAMs). The guidance has been widely welcomed by regulators and safety assessors as a critical step toward strengthening confidence in non-animal approaches for cosmetic ingredient safety evaluation. As regulatory frameworks worldwide continue to advance toward animal-free safety decisions, implementation is the decisive next step. To support this transition, ICCS is convening a free, in-depth webinar focused on how the Guidance can be applied in real-world regulatory risk assessments for skin sensitization. From guidance to practice: This session will demonstrate how defined approaches under OECD Guideline 497— including the 2 out of 3 (2o3), the Integrated Testing Strategy (ITS), and the SARA-ICE model—can be used together within practical, decision-ready risk assessment workflows. Webinar Details Thursday, April 9, 2026 1:00 – 4:30 PM CET Format: Virtual | Free to Attend Speakers and Presentations Donna Macmillan, PhD – Director, Outreach & Capacity Building, ICCS An Introduction to the ICCS Best Practice Guidance Document on Skin Sensitization Petra Kern, PhD – Senior Toxicologist/Risk Assessor, Procter & Gamble A Deep Dive into OECD GL 497 Defined Approaches: 2o3 and ITS Georgia Reynolds, MSc – Safety Science Leader, Unilever Applying OECD GL 497 Defined Approaches: SARA-ICE Nathalie Alépée, PhD – Research Toxicologist & Scientific Officer, L’Oréal The ICCS BPG on Skin Sensitization in Practice: A Case Study The webinar will provide live Q&A, offering attendees the opportunity to engage directly with the speakers and discuss practical, regulatory-relevant questions. Who Should Attend This session is designed for regulatory scientists, safety assessors, and technical experts working across regulatory agencies, industry, and associated research organizations who are involved in skin sensitization assessment and the application of NAM-based evidence.  Join ICCS and leading experts to explore how NAMs can be confidently applied in regulatory practice and help support robust decision-making without the use of animals.
More Posts